Patrick Willoughby

Patrick Willoughby

Assistant Professor of Chemistry
Office: Farr 304

  • Basic Information
  • Awards & Honors
  • Publications
  • Areas of Interest
  • Professional Affiliations

Basic Information


  • University of Northern Iowa, B.S., Chemistry, 2008
  • University of Minnesota, Ph.D., Chemistry, 2013

Courses Taught

  • Organic Chemistry I
  • Organic Chemistry II
  • Advanced Organic Chemistry
  • Advanced Laboratory
  • Guided Studies into Polymer Chemistry

Awards & Honors

  • May Bumby Severy, Class of 1908, Award 2016
  • NSF Graduate Research Fellowship 2010-2013
  • Wayland E. Noland Outstanding Graduate Teaching Award 2010
  • University of Minnesota Graduate School Fellowship 2008
  • University of Northern Iowa Purple and Old Gold Award 2008
  • Barry M. Goldwater Scholarship 2007


  • Enright, R. N.; Grinde, J. L.; Wurtz, L. I.; Paeth, M. S.; Wittman, T. R.; Cliff, E. R.; Sankari, Y. T.; Henningsen, L. T.; Tan, C.; Scanlon, J. D.; Willoughby, P. H. Synthesis of N,O-acetals by net amide C–N bond insertion of aldehydes into N-acyl phthalimides and N-acyl azoles. Tetrahedron 2016, 72, 6397–6408.
  • Willoughby, P. H.; Enright, R. N.; Henningsen, L. T. Methods and Intermediates Useful for the Preparation of alpha-Branched Aryl Phthalimides and alpha-Branched Aryl Amines. US Patent 62,101,277, January 6, 2016.
  • Resende, G. C.; Alvarenga, E. S.; Willoughby, P. H. Isolation and Stereochemical Assignment of Phthalides Resulting from the Diels–Alder Reaction Between 5-Isopropoxyfuran-2(5H)-one and Cyclopentadiene. J. Mol. Struct. 2015, 1101, 212–218.
  • Willoughby, P. H.; Niu, D.; Wang, T.; Haj, M. K.; Cramer, C. J.; Hoye, T. R. Mechanism of the Reactions of Alcohols with o-Benzynes. J. Am. Chem. Soc. 2014, 136, 13657–13665.
  • “Generation of Gaussian 09 Input Files for the Computation of 1H and 13C NMR Chemical Shifts of Structures from a Spartan’14 Conformational Search,” Reisbick, S.; Willoughby, P. Protocol Exchange 2014, Community Contribution.
  • “A Guide to Small-Molecule Structure Assignment Through Computation of (1H and 13C) NMR Chemical Shifts,” Willoughby, P. H.; Jansma, M. J.; Hoye, T. R. Nature Protocols 2014, 9, 643–660.
  • “Alkane Desaturation by Concerted Double Hydrogen Atom Transfer to Benzyne,” Niu, D.; Willoughby, P. H.; Woods, B. P.; Baire, B.; Hoye, T. R. Nature 2013, 501, 531–534.
  • “Synthesis of Complex Benzenoids via the Intermediate Generation of o-Benzynes Through the Hexadehydro-Diels–Alder Reaction,” Baire, B.; Niu, D.; Willoughby, P. H.; Woods, B. P.; Hoye, T. R. Nature Protocols 2013, 8, 501–508.
  • “Cyclization Methods,” Hoye, T. R.; Baire, B.; Niu, D.; Willoughby, P. H.; Woods, B. P. US Patent 13,756,069, January 13, 2013.
  • “The Hexadehydro-Diels–Alder Reaction,” Hoye, T. R.; Baire, B.; Niu, D.; Willoughby, P. H.; Woods, B. P. Nature 2012490, 208–212.
  • “Decarboxylative Isomerization of N-Acyl-2-oxazolidinones to 2-Oxazolines,” May, A. E.; Willoughby, P. H.; Hoye, T. R.; J. Org. Chem. 2008, 73, 3292–3294.
  • “On the Heat of Formation of Nitromethane,” Bumpus, J. A.; Willoughby, P. H. J. Phys. Org. Chem. 2008, 21, 747–757.

Areas of Interest

  • Organic synthesis
  • Catalysis
  • Natural products

Professional/Scholarly Affiliations

  • American Chemical Society
  • Lilly Open Innovation Drug Discovery Program coordinator at Ripon College